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2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors

✍ Scribed by A Rao; J Balzarini; A Carbone; A Chimirri; E De Clercq; A.M Monforte; P Monforte; C Pannecouque; M Zappalà


Book ID
113457128
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
84 KB
Volume
63
Category
Article
ISSN
0166-3542

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AbstractÐBenzothiadiazine non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV have been synthesized via a novel process to aord active inhibitors, with the most potent compound exhibiting an IC 90 =180 nM in a whole cell assay. The 2,2dioxide-1H-2,1,3-benzothiadiazine ring system was con