1α,25-Dihydroxyvitamin D3 Hybrid Analogs
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Gary H. Posner; Jae Kyoo Lee; Zhengong Li; Kazuhiro Takeuchi; Sandra E. Guggino;
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Article
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1995
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Elsevier Science
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English
⚖ 297 KB
Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (+)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities. We recently proposed and evaluated a new concept