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1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

✍ Scribed by Gary H. Posner; M.Christina White; Patrick Dolan; Thomas W. Kensler; Shigefumi Yukihiro; Sandra E. Guggino


Book ID
108477023
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
513 KB
Volume
4
Category
Article
ISSN
0960-894X

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1α,25-Dihydroxyvitamin D3 Hybrid Analogs
✍ Gary H. Posner; Jae Kyoo Lee; Zhengong Li; Kazuhiro Takeuchi; Sandra E. Guggino; 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 297 KB

Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (+)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities. We recently proposed and evaluated a new concept