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1H NMR studies of urine from premature and sick babies

✍ Scribed by Judith C. C. Brown; Graham A. Mills; Peter J. Sadler; Valerie Walker

Book ID
102954463
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
523 KB
Volume
11
Category
Article
ISSN
0740-3194

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✦ Synopsis

High-frequency proton nuclear magnetic resonance ('H NMR) has been applied to a study of urine from premature and sick newborn babies with a variety of clinical disorders. These included severe birth asphyxia, necrotizing enterocolitis, ketosis, and drug treatment. Abnormal levels of metabolites such as lactate, ketone bodies, betaine, dicarboxylic acids, and 4-hydroxyphenolic acids were detected, as was the antibiotic metronidazole and one of its metabolites. The assignment of betaine was confirmed by twodimensional 'H NMR studies of urine obtained from two adults with homocystinuria receiving treatment with oral betaine. High-resolution 'H NMR spectroscopy of urine is a potentially useful research technique for monitoring metabolism during early life.

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