1H NMR studies of human urine: Urinary elimination of the anticancer drug carboplatin

✍ Scribed by John D. Ranford; Peter J. Sadler; Katherine Balmanno; David R. Newell

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 383 KB
• Volume: 29
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1260291321

✦ Synopsis

Abstract

Samples of urine from a patient obtained before and after treatment with 300 mg of the anticancer drug [Pt(II)(NH~3~)2(CBDCA)] (carboplatin, “Paraplatin”, where CBCDA is 1,1‐dicarboxycyclobutane) have been analysed using 500 MHz 1D and 2D ^1^H NMR spectroscopy. Peaks for the intact drug and the free ligand CBDCA have been assigned and are present in a mol ratio of ca. 5:1. Only about one half of the total Pt in the sample was present as intact drug. Relative to creatinine and citrate, the excretion of hippurate increased by a factor of ca. 4 after drug treatment. This work suggests that NMR spectroscopy can play a valuable rǒle in studies of carboplatin metabolism.