✦ LIBER ✦

1h nmr observation of tissue myoglobin: an indicator of cellular oxygenation in vivo

✍ Scribed by T. Jue; S. Anderson

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 291 KB
Volume: 13
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910130322

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cellular oxygen status is a critical parameter. To measure the oxygen tension in vivo, however, demands extant techniques to surmount two experimental difficulties: invasive experimental protocols and imprecise tissue localization. NMR techniques have the potential to overcome these obstacles. Indeed we show in this study that cellular myoglobin is NMR visible and its proximal histidyl NH signal in the deoxy state can be used to monitor changes in cellular oxygenation. Coupled with recent advances in NMR signal localization, this ^1^H NMR strategy promises to lead directly to cellular oxygen measurement in specific tissue regions in vivo.

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