✦ LIBER ✦
Neurometabolic effects of an inborn error of amino acid metabolism demonstrated in vivo by 1H NMR
✍ Scribed by David G. Gadian; Edward Proctor; Stephen R. Williams; Ernest B. Cady; R. Mark Gardiner
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 409 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
The elevated levels of brain histidine in histidinaemic mice are detected in vivo by 1H NMR at 8.5 and 1.9 T. The concentrations determined from the in vivo spectra correlate well with subsequent analytical determinations. This technique is discussed in relation to monitoring phenylalanine in humans with phenylketonuria.