✦ LIBER ✦

1H NMR Analysis of Isocyclosporin A Prepared in Organic Solvent and in Aqueous Solution

✍ Scribed by Lolita Arnoldi; Ada Manzocchi; Fulvio Magni; Marina Del Puppo; Marzia Galli Kienle

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 194 KB
Volume: 25
Category: Article
ISSN: 0045-2068
DOI: 10.1006/bioo.1997.1058

No coin nor oath required. For personal study only.

✦ Synopsis

Isocyclosporins are isomers of cyclosporins deriving from an N,O-acyl transfer occurring under acidic conditions. For the identification by 1 H NMR of isocyclosporins prepared in organic solvents the signal at 2.3 ppm assigned to three hydrogens of the NHCH 3 group is considered. Results reported here show that the 1 H NMR spectrum of isocyclosporin A prepared in aqueous acidic conditions lacks of the above signal and profoundly differs from that of isocyclosporin A prepared in organic solvents, despite the identity of the primary structures determined on the basis of mass spectrometric analysis.

📜 SIMILAR VOLUMES

1H and 13C NMR spectra of spiramycin I i

1H and 13C NMR spectra of spiramycin I in organic and aqueous solutions

✍ Perwaiz Alam; Jill Barber; Richard J. Brennan; Karen Kennedy; M. Hassan H. Tehra 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 229 KB 👁 1 views

## Abstract Full assignments of the ^1^H and ^13^C NMR spectra of spiramycin l in CDCl~3~ and buffered D~2~O were carried out unambiguously using a range of 1D and 2D NMR methods.

Assignments of the 1H and 13C NMR Spectr

Assignments of the 1H and 13C NMR Spectra of Anhydroerythromycin A in Organic and Aqueous Solutions

✍ P. Alam; P. C. Buxton; K. J. Embrey; J. A. Parkinson; J. Barber 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 2 views

The 'H and "C NMR spectra of anhydroerythromycin A in methanol-d, and buffered D,O have been fully assigned using a range of one-and two-dimensional N M R techniques.

Assignments of the 1H and 13C NMR Spectr

Assignments of the 1H and 13C NMR Spectra of Anhydroerythromycin A in Organic and Aqueous Solutions

✍ P. Alam; K. J. Embrey; J. A. Parkinson; J. Barber 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 2 views

The 'H and 13C N M R spectra of anhydroerythromycin A in methanol-d, and buffered D,O have been fully assigned using a range of one-and two-dimensional NM R techniques.

Conformational Analysis of a Branched Su

Conformational Analysis of a Branched Sugar in Aqueous Solution Based on Molecular Mechanics and 1H-NMR Studies

✍ Haruo Yamada; Takeo Harada; Takashi Takahashi 📂 Article 📅 1995 🏛 Elsevier Science 🌐 French ⚖ 224 KB

ChemInform Abstract: Solution Structure

ChemInform Abstract: Solution Structure and Assignments of the 1H and 13C NMR Spectra of Erythromycin C in Organic and Aqueous Solution.

✍ Paul Tyson; Herve Barjat; Warren Mann; Jill Barber 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

Conformational features of imipramine hy

Conformational features of imipramine hydrochloride in aqueous solution as detected by 1H NMR relaxation analysis

✍ Elena Gaggelli; Nadia Marchettini; Gianni Valensin 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 312 KB

## Abstract Proton NMR measurements were performed and ^1^H^1^H dipolar interaction energies were measured to delineate the conformation of imipramine in solution. Self‐association of imipramine into dimers was observed and a dimerization constant of 121 mol^−1^ was calculated. The motional correl