The synthesis of the title compound is described. It involves base catalyzed substitution of deuterium for hydrogen in 3-p- -chlorophenylglutaric acid which is subsequently transformed to baclofen. The overall yield is 80%. ## INTRODUCTION AND DISCUSSION In order to develop a mass fragmentographi
1H and 13C NMR determination of the enantiomeric purity of 4-amino-3-(4-chlorophenyl)-butyric acid
β Scribed by Claude Vaccher; Pascal Berthelot; Nathalie Flouquet; Michel Debaert; Rene Guyon; Gaston Vermeersch
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 84 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1386-1425
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π SIMILAR VOLUMES
## Abstract Two preparations of carbonβ14 labelled 4βaminoβ3β(4βchlorophenyl)βbutyric acid are described : First, the label is introduced in the 3βposition of the butyric acid chain in nine steps, starting from ^14^CO~2~. The total radiochemical yield is 30%, calculated from the first labelled inte
A Simple and Efficient New Approach to the Total Synthesis of (Β±)-4-Amino-3-(4-chlorophenyl)-butyric Acid (Baclofen). -A new approach to the total synthesis of Baclofen (VI) involving the ( 2 + 2) cycloaddition between dichloroketene, generated from trichloroacetyl chloride (II), and olefin (I) as