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1H and 13C NMR conformational analysis in solution of isoproterenol a pure β-agonist drug

✍ Scribed by Elena Gaggelli; Nadia Marchettini; Gianni Valensin

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 478 KB
Volume: 25
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260251109

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✦ Synopsis

13C and 'H NMR parameters were measured for isoproterenol in solution. Spin-lattice relaxation rates were considered and C-H and H-H J couplings were determined. The t rotamer was shown to occur in a much greater abundance than the two g rotamers. Dynamics in solution were interpreted in terms of a nearly isotropic motion of the a-hydroxyphenethyl moiety and of a high degree of flexibility of the isopropyl moiety, Relevant distances and dipolar connectivities were measured and used to build up a Dreiding model of the most probable conformation.

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