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199 IGFBP-3 promoter methylation activates the PI3K/Akt intracellular signaling pathway in CDDP resistant cell lines

✍ Scribed by M. Cortés; M. de Miguel; C. Belda-Iniesta; M. Nistal; R. Perona; I. Ibanez de Caceres


Book ID
119601986
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
8
Category
Article
ISSN
1359-6349

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## Abstract Despite its well‐defined role as a serum growth factor during fetal liver development and hepatic oncogenesis, the biological significance of cytoplasmic alpha‐fetoprotein (AFP) remains incompletely understood. Here, we provide evidence to illustrate that cytoplasmic AFP may function as