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193 Cellular localization of urokinase-type plasminogen activator, its inhibitors and their mRNAs in breast cancer tissues

Book ID
117439789
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
80 KB
Volume
12
Category
Article
ISSN
0268-9499

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The plasminogen activation (PA) system may participate in cancer invasion and metastasis. A series of breast cancer tissue specimens was analysed using in situ hybridization and immunohistochemistry. Urokinase-type plasminogen activator (u-PA) mRNA was detected in cancer cells and fibroblasts adjace

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The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in tumour invasion. Previous studies have shown by RT-PCR that uPA and uPAR mRNAs are expressed in human hepatocellular carcinoma (HCC). Here, in situ hybridization, immunohistochemistry, and double immunoΒ―