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19-hydroxy-4-androsten-17-one: Potential competitive inhibitor of estrogen biosynthesis

โœ Scribed by Mitsuteru Numazawa; Ayako Mutsumi; Kumiko Hoshi; Ryoji Koike


Book ID
117058868
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
293 KB
Volume
160
Category
Article
ISSN
0006-291X

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19-acetylenic, 19-hydroxy-androst-4-en-3
โœ Douglas F. Coveyy; Vinod D. Parikh; Walter W. Chien ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 171 KB

Steroids designed as potential suicide substrates of estrogen biosynthesis are reported. Enzyme inhibition resulting from covalent modification should occur if these acetylenic alcohols are converted into a reactive acetylenic ketone by the aromatase enzyme system.