19-acetylenic, 19-hydroxy-androst-4-en-3,17-diones. Potential suicide substrates of estrogen biosynthesis

✍ Scribed by Douglas F. Coveyy; Vinod D. Parikh; Walter W. Chien

• Book ID: 104237747
• Publisher: Elsevier Science
• Year: 1979
• Tongue: French
• Weight: 171 KB
• Volume: 20
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)86274-2

✦ Synopsis

Steroids designed as potential suicide substrates of estrogen biosynthesis are reported. Enzyme inhibition resulting from covalent modification should occur if these acetylenic alcohols are converted into a reactive acetylenic ketone by the aromatase enzyme system.