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18O labeled nucleosides. 1. A general method for the synthesis of specifically labeled pyrimidine deoxyribosides

✍ Scribed by Karl H. Schram; Steven Ratcliff; John Neenan

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
262 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A facile method for the preparation of ^18^O labeled pyrimidine deoxyribosides is described. The method provides a means of selectively labeling the base, sugar or both the base and sugar moieties with high levels of ^18^O. Thymidine is used as a model to illustrate the method. The site and level of label was established using mass spectrometry.

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