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17α-Ethynyl-17β-hydroxy­androsta-1,4-dien-3-one

✍ Scribed by Sheng, Liu-Qing ;Liang, Wan-Gen ;Chen, Gang ;Shen, Hua-Feng

Publisher
International Union of Crystallography
Year
2007
Tongue
English
Weight
259 KB
Volume
63
Category
Article
ISSN
1600-5368

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✦ Synopsis

In the title molecule, C~21~H~26~O~2~, there are two C=C bonds [1.321 (4) and 1.334 (4) Å], which contribute to the planarity of ring A along with the carbonyl group. Rings B and C have regular chair conformations, while ring D has an envelope conformation. In the crystal structure, intermolecular O—H...O and C—H...O hydrogen bonds link the molecules into corrugated sheets parallel to the ab plane.

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## Abstract A biotransformation process using __Mycobacterium__ sp was studied for androsta‐1, 4‐diene‐3,17‐dione (ADD) and androsta‐4‐ene‐3,17‐dione (AD) production from cholesterol. Cholesterol has a poor solubility in water (∼1.8 mg dm^−3^ at 25 °C), which makes it difficult to use as the substr