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17 β-estradiol and not genistein modulates lacI mutant frequency and types of mutation induced in the heart of ovariectomized big blue rats treated with 7, 12-dimethylbenz[a]anthracene

✍ Scribed by Mugimane G. Manjanatha; Sharon D. Shelton; Bobbie S. Rhodes; Michelle E. Bishop; Lascelles E. Lyn-Cook; Aname Aidoo


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
140 KB
Volume
45
Category
Article
ISSN
0893-6692

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An important question regarding the use of transgenic reporter genes to detect mutation in rodents is how the types of mutations recovered in transgenes compare with the types of mutations found in endogenous genes. In this study, we examined mutations induced by 7,12-dimethylbenz[a]anthracene in th