16q loss of heterozygosity and microsatellite instability in Wilms' tumor
β Scribed by John E Mason; Paul J Goodfellow; Paul E Grundy; Michael A Skinner
- Book ID
- 117826775
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 80 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-3468
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## Abstract Chromosome arm 16q is a common site of loss of heterozygosity (LOH) in Wilms tumors (WTs). The mechanism and consequences of 16q LOH are not known, but the __CTCF__ gene, in band 16q22, is a candidate target gene. CTCF protein binds to DNA upstream of the __H19__ gene on chromosome band
To assess the frequency of loss of heterozygosity (LOH) and microsatellite instability (MI) in oligodendrogliomas, we performed an extensive screening of 16 oligodendrogliomas and nine anaplastic oligodendrogliomas by using 132 microsatellite markers on chromosomes 1 through 12 and 15 through 21. In