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16q heterozygosity loss in Wilms» tumour in children and its clinical importance

✍ Scribed by G Skotnicka-Klonowicz; P Rieske; J Bartkowiak; S Szymik-Kantorowicz; P Daszkiewicz; M Debiec-Rychter

Book ID
117817490
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
96 KB
Volume
26
Category
Article
ISSN
0748-7983

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Chromosome arm 16q in Wilms tumors: Unba
Chromosome arm 16q in Wilms tumors: Unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene
✍ Albert Yeh; Michelle Wei; Samuel B. Golub; Darrell J. Yamashiro; Vundavali V. Mu 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 666 KB

## Abstract Chromosome arm 16q is a common site of loss of heterozygosity (LOH) in Wilms tumors (WTs). The mechanism and consequences of 16q LOH are not known, but the __CTCF__ gene, in band 16q22, is a candidate target gene. CTCF protein binds to DNA upstream of the __H19__ gene on chromosome band