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165 Mannan-binding-lectin-associated serine protease 2 (MASP-2)—a major modifier of CF lung disease?

✍ Scribed by H.V. Olesen; J.C. Jensenius; R. Steffensen; S. Thiel; P.O. Schiøtz


Book ID
118640776
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
127 KB
Volume
5
Category
Article
ISSN
1569-1993

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Genetic influences on mannan-binding lec
✍ Grith L. Sorensen; Inge Petersen; Steffen Thiel; Mogens Fenger; Kaare Christense 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB

## Abstract The lectin pathway of the complement system is activated when Mannan‐binding lectin (MBL) in complex with MASP‐2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease. The present s