In the literature the sensitization of DNA to radiationinduced damage by caffeine has been attributed to an override of the G2/M block. This process was supposed to involve the tumor suppressor gene p53 as it was described that p53 negative cells were more sensitive to checkpoint inhibition by caffe
162 Differential sensitivity of P53+ and P53- cells to caffeine-induced radiosensitization and override of G2 delay
✍ Scribed by S.N. Powell; J.S. DeFrank; P. Connell; M. Eogan; F. Preffer; D. Dombkowski; W. Tang; S.H. Friend
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 118 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0360-3016
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p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh
## Abstract The tumor‐suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor‐suppressor activity by either causing cell‐cycle arrest (G~1~/S or G~2~/M) or inducing cells to undergo apoptosis. This function of wild‐type p53 as “guardia