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16. Liver production of insulin-like growth factors (IGF-1; IGF-2) mediate bovine growth hormone (bGH) action on bovine mammary gland in culture

✍ Scribed by L. Shkreta; P.A. Accorsi; R. Gaiani; F. Chiesa


Book ID
117461457
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
123 KB
Volume
50
Category
Article
ISSN
0301-6226

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✍ Constance J. Grill; Wendie S. Cohick πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 215 KB πŸ‘ 2 views

IGF-I is mitogenic for the bovine mammary epithelial cell line MAC-T. In addition, IGF-I specifically upregulates IGFBP-3 synthesis in these cells. To investigate this effect on cell growth and IGF-I responsiveness, cell lines were developed that constitutively express IGFBP-3. MAC-T cells transfect