𝔖 Bobbio Scriptorium
✦   LIBER   ✦

15N-NMR Spectroscopy, 15. The Structure of Streptomycin in Solution

✍ Scribed by Hull, William E. ;Kricheldorf, Hans R.

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
398 KB
Volume
1980
Category
Article
ISSN
0947-3440

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The natural abundance ^15^N‐NMR spectra of streptomycin and dihydrostreptomycin in aqueous solution at pH 5 show conclusively that the aldehyde group of streptomycin does not react with the methylamino or guanidino groups internally to form a four‐ring structure. ^13^C‐NMR data provide strong evidence that the aldehyde group forms a hydrate which is stabilized by the hydroxy group at C‐3 of L‐streptose.

πŸ“œ SIMILAR VOLUMES

15N NMR spectroscopy of some azines
15N NMR spectroscopy of some azines
✍ L. Stefaniak; John D. Roberts; M. Witanowski; G. A. Webb πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 451 KB
Characterization of biguanides by 15N NM
Characterization of biguanides by 15N NMR spectroscopy
✍ B. Clement; U. Girreser πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 82 KB πŸ‘ 2 views

The monoprotonated biguanides phenformin hydrochloride, buformin hydrochloride and metformin hydrochloride were investigated by 15 N NMR spectroscopy. The structure of all hydrochlorides is best described by a 1,3-diazabutadienic skeleton with three amino groups and its corresponding mesomeric forms