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Characterization of biguanides by 15N NMR spectroscopy

✍ Scribed by B. Clement; U. Girreser

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 82 KB
Volume: 37
Category: Article
ISSN: 0749-1581
DOI: 10.1002/(sici)1097-458x(199909)37:9<662::aid-mrc518>3.0.co;2-d

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✦ Synopsis

The monoprotonated biguanides phenformin hydrochloride, buformin hydrochloride and metformin hydrochloride were investigated by 15 N NMR spectroscopy. The structure of all hydrochlorides is best described by a 1,3-diazabutadienic skeleton with three amino groups and its corresponding mesomeric forms. There is no evidence for the presence of other tautomeric forms in solution.

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