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15N Conservation in the Metabolic Conversion of Isoleucine to Alloisoleucine in the Rat

✍ Scribed by Mamer, Orval A.; Lépine, François L.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
733 KB
Volume
31
Category
Article
ISSN
1076-5174

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✦ Synopsis

1sN,13C,-~-Isoleucine was given by stomach tube to a pair of rats and the urine excreted over the following 6 h period was collected. The urinary amino acid fraction showed that the majority of the L-alloisoleucine produced from the labeled isoleucine was formed with the "N label intact. This fails to support the commonly held supposition that L-isoleucine and ~-alloisoleucine interconversion occurs through the reversible enolization of the 2-keto-3methylvaleric acids formed by their transamination. In contrast to "N label conservation in Lalloisoleucine, the majority of the "N in the administered L-isoleucine underwent exchange with 14N.

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