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159 INVITED Targeting MEK in tumors with BRAF and RAS mutations

โœ Scribed by D. Solit

Book ID
118625116
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
57 KB
Volume
5
Category
Article
ISSN
1359-6349

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โœ Flaherty, Keith T.; Infante, Jeffery R.; Daud, Adil; Gonzalez, Rene; Kefford, Ri ๐Ÿ“‚ Article ๐Ÿ“… 2012 ๐Ÿ› Massachusetts Medical Society ๐ŸŒ English โš– 528 KB

## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a