𝔖 Bobbio Scriptorium
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155 Polymorphic imprinting of PEG1/MEST gene: A susceptibility factor for liver disease?


Book ID
117373667
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
254 KB
Volume
42
Category
Article
ISSN
0168-8278

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Alpha(1)-antitrypsin deficiency (AATD) due to homozygosity of the protease inhibitor (Pi) Z variant predisposes to childhood liver disease and pulmonary emphysema. About 10% of all neonates with AATD develop liver disease, and about 3% overall progress to severe disease. AATD is a principal genetic