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Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease

✍ Scribed by Harri A. Järveläinen; Arto Orpana; Markus Perola; Vesa T. Savolainen; Pekka J. Karhunen; Kai O. Lindros


Book ID
118686799
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
95 KB
Volume
33
Category
Article
ISSN
0270-9139

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Alpha(1)-antitrypsin deficiency (AATD) due to homozygosity of the protease inhibitor (Pi) Z variant predisposes to childhood liver disease and pulmonary emphysema. About 10% of all neonates with AATD develop liver disease, and about 3% overall progress to severe disease. AATD is a principal genetic