𝔖 Bobbio Scriptorium
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15/17 Translocation in acute promyelocytic leukaemia

✍ Scribed by J. M. J. C. Scheres; T. W. J. Hustinx; G. A. M. Vaan; F. J. Rutten

Publisher
Springer
Year
1978
Tongue
English
Weight
224 KB
Volume
43
Category
Article
ISSN
0340-6717

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✦ Synopsis

A translocation between a chromosome 15 and a chromosome 17 was found in the bone marrow of a 14-year-old boy who had clinical and laboratory symptoms of acute promyelocytic leukemia (APL). As far as we know, this is the sixth case of APL with 15/17 translocation to be reported in the literature. This observation gives further support to the hypothesis that there is an association between this chromosomal rearrangement and APL.

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## Abstract Acute promyelocytic leukemia (APL; M3 in the FAB classification) is specifically associated with the t(15;17)(q23;q12) and the consequent formation of a __PML/RARA__ fusion gene. A few cases of APL with a t(11;17)(q23;q12) and a __PLZF/RARA__ fusion gene have recently been reported. In