( 15 N 5 )-Labeled Adenine Derivatives: Synthesis and Studies of Tautomerism by 15 N NMR Spectroscopy and Theoretical Calculations
β Scribed by Laxer, Avital; Major, Dan T.; Gottlieb, Hugo E.; Fischer, Bilha
- Book ID
- 120885059
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 312 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Comparison of the "C and "N NMR spectra of 8-azatheophylline with those of its three methylated derivatives and other model compounds from the literature showed that 8-azatheophylline exists to the extent of 80% in the N-2 tautomeric form in DMSO solution.
The relative axialΓequatorial position of spiro[4.5]decanes substituted in the 1,4-positions by oxygen or nitrogen were assigned by 15N and 17O NMR spectroscopy. The substituent, chemical exchange and steric e β ects upon the chemical shifts are discussed. A linear relationship between 15N and 17O wa