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15-Deoxy-Δ12,14-prostaglandin-J2reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation

✍ Scribed by Gemma Olmos; María I. Arenas; Raquel Bienes; María Jose Calzada; Julián Aragonés; Maria Laura Garcia-Bermejo; Manuel O. Landazuri; Javier Lucio-Cazaña

Book ID
105758918
Publisher
Springer
Year
2009
Tongue
English
Weight
657 KB
Volume
66
Category
Article
ISSN
1420-682X

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Inhibition of interleukin-1β–induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Δ12,14-prostaglandin J2 through a histone deacetylase–independent mechanism
✍ Katherine Farrajota; Saranette Cheng; Johanne Martel-Pelletier; Hassan Afif; Jea 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB 👁 1 views

Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the