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15-Deoxy-delta12,14-prostaglandin-J2 up-regulates cyclooxygenase-2 but inhibits prostaglandin-E2 production through a thiol antioxidant-sensitive mechanism

✍ Scribed by Patricia Reyes-Martin; Sara Ramirez-Rubio; Trinidad Parra-Cid; Raquel Bienes-Martínez; Javier Lucio-Cazana

Book ID
119346524
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
595 KB
Volume
57
Category
Article
ISSN
1043-6618

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Inhibition of interleukin-1β–induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Δ12,14-prostaglandin J2 through a histone deacetylase–independent mechanism
✍ Katherine Farrajota; Saranette Cheng; Johanne Martel-Pelletier; Hassan Afif; Jea 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB 👁 1 views

Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the