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1(4H)-Naphthalenones in anthracyclinone synthesis: a new route for the total synthesis of (.+-.)-aklavinone

โœ Scribed by Hauser, Frank M.; Hewawasam, Piyasena; Rho, Young S.


Book ID
127295574
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
733 KB
Volume
54
Category
Article
ISSN
0022-3263

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โœ Roeland C. Vollinga; Wiro M. P. B. Menge; Hendrik Timmerman ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 293 KB

## Abstract A new route for the synthesis of 4(5)โ€(ฯ‰โ€aminoalkyl)โ€1 __H__โ€imidazoles 1 on a preparative scale through C5 lithiation of a 1,2โ€diprotected imidazole is described. When the described 1,2โ€diprotected 5โ€lithioโ€imidazole is treated with a 1โ€chloroโ€ฯ‰โ€iodoalkane 5, selective substitution of