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14C-labelling of a novel antiischaemic adenosine A1 agonist at purine C-8

✍ Scribed by Jacob S. Valsborg; Lars J. S. Knutsen; Christian Foged

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 391 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199605)38:5<497::aid-jlcr855>3.0.co;2-b

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✦ Synopsis

SUM MARY

A ''C-labelled form of 2-chloro-K[(R)-(2-benzoxazolyl)thio-2-propyl]adenosine a, a novel antiischaemic adenosine A, agonist, has been prepared in three steps from [8- '4C]-9-(2,3,5-tri-0-benzoyl-~-D-ribofuranosyl)-2,6-dichloropurine a. The overall radiochemical yield was 56%. The radiochemical purity was higher than 98% with a specific radioactivity of 36 mCi/mmol.

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