144. Induction of monocytic leukemia cell differentiation by nitric oxide, a stromal cell-derived, nonprotein growth-inhibiting molecule

Involvement of a transforming-growth-fac

Involvement of a transforming-growth-factor-β-like molecule in tumor-cell-derived inhibition of nitric-oxide synthesis in cerebral endothelial cells

✍ Jun-Ichi Murata; Sally Betz Corradin; Emanuela Felley-bosco; Lucienne Juillerat- 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 797 KB

Nitric oxide (NO) has been shown to exert cytotoxic effects on tumor cells. W e have reported that EC2 I 9 cells, a rat-brainmicrovessel-derived endothelial cell line, produced NO through cytokine-inducible NO synthase (iNOS), the induction of which was significantly decreased by (a) soluble factor(