1,4-Bis(arylsulfonyl)dihydropyridines in synthesis. Enantioselective synthesis of 2,3,6-trisubstituted piperidines
โ Scribed by Santiago Carballares; Donald Craig
- Book ID
- 108346846
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 86 KB
- Volume
- 624
- Category
- Article
- ISSN
- 0022-328X
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1,4-Bis(4-tolylsulfonyl)-1,2,3,4-tetrahydropyridines undergo stereoselective S N 1 reactions with soft carbon nucleophiles in the presence of Lewis acids. Subsequent dihydroxylation of the double bond followed by esterification enables the stereoselective preparation of substituted piperidines.