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13C NMR investigation of synovial fluids

✍ Scribed by Klaus Albert; Sabine Michele; Ulrich Günther; Manfred Fial; Hugo Gall; Johannes Saal


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
356 KB
Volume
30
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis


Abstract

^13^C NMR spectra of synovial fluids from 20 patients suffering from rheumatic diseases have been recorded. Structural changes in hyaluronic acid, the main carrier of the viscoelastic properties of synovial fluid, could be observed in the NMR spectra of the native biological fluid. By comparing these spectra with those of purified hyaluronic acid, a rough estimation of the degree of depolymerization of synovial hyaluronlic acid was possible. The patients with rheumatoid arthritis appeared to have a lower degree of polymerization compared to patients with osteoarthrosis. Thus, ^13^C NMR spectroscopy prolvides useful information about biophysical properties of sartorial fluid.


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