A series of 14 3-substituted 4-oxoquinolones with or without a substituent (methyl, ethyl) in position 1 were prepared. Literature and measured data were used to study the inÑuence of the substituent on the shifts of carbon atoms of these compounds, which are model compounds for antibacterial drugs
13C NMR investigation of some hetero-ring substituted 2- and 4-quinolone systems
✍ Scribed by G. M. Coppola; A. D. Kahle; M. J. Shapiro
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 379 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Abstract
A series of 2‐ and 4‐quinolones substituted in the hetero‐ring have been evaluated using ^13^C NMR techniques. Substituent effects are discussed as an aid to evaluation of potential tautomerization in the 2‐quinolone systems. The observed substituent shifts for systems having a hydroxy function at the 4‐position in the 2‐quinolones can be explained without implementing the tautomerism to a 4‐quinolone.
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