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1,3,4-Dioxazol-2-ones: a potentially hazardous class of compounds

✍ Scribed by Middleton, William J.


Book ID
121411344
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
468 KB
Volume
48
Category
Article
ISSN
0022-3263

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2-Alkylidene-benzo[1,3]dioxin-4-ones: a
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A new class of compounds, 2-alkylidene-benzo[1,3]dioxin-4-ones, have been synthesised by cyclisation of the corresponding o-acyloxy benzoyl chlorides with triethylamine. The 2-methylene-benzo[1,3]dioxin-4-one acts as a prodrug for aspirin and is a useful intermediate in the synthesis of new aspirin

3-(1-Hydroxyalkyl)-1,4,2-dioxazol-5-one
✍ Geffken, Detlef 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 377 KB

## Abstract 2‐Hydroxycarbohydroxamsäuren **6** reagieren mit 1,1′‐Carbonyldiimidazol zu 3‐(1‐Hydroxyalkyl)‐1,4,2‐dioxazol‐5‐onen **7** und 3‐Hydroxyoxazolidin‐2,4‐dionen **8**, wobei die Cyclisierung in Richtung **7** und **8** durch die Substitution an __C‐2__ von **6** bestimmt wird. In Gegenwart