A new class of compounds, 2-alkylidene-benzo[1,3]dioxin-4-ones, have been synthesised by cyclisation of the corresponding o-acyloxy benzoyl chlorides with triethylamine. The 2-methylene-benzo[1,3]dioxin-4-one acts as a prodrug for aspirin and is a useful intermediate in the synthesis of new aspirin
✦ LIBER ✦
1,3,4-Dioxazol-2-ones: a potentially hazardous class of compounds
✍ Scribed by Middleton, William J.
- Book ID
- 121411344
- Publisher
- American Chemical Society
- Year
- 1983
- Tongue
- English
- Weight
- 468 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-3263
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## Abstract 2‐Hydroxycarbohydroxamsäuren **6** reagieren mit 1,1′‐Carbonyldiimidazol zu 3‐(1‐Hydroxyalkyl)‐1,4,2‐dioxazol‐5‐onen **7** und 3‐Hydroxyoxazolidin‐2,4‐dionen **8**, wobei die Cyclisierung in Richtung **7** und **8** durch die Substitution an __C‐2__ von **6** bestimmt wird. In Gegenwart