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1,3-Phosphorotropic rearrangement of pyridyl phosphates to hydroxypyridyl phosphonates

✍ Scribed by Peter P. Onys'ko; Elena A. Suvalova; Tatiana I. Chudakova; Anatolii D. Sinitsa

Book ID: 102227903
Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 298 KB
Volume: 4
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.520040408

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✦ Synopsis

Abstract

The lithium diisopropylamide (LDA) induced regioselective 1,3‐rearrangement of 3‐ and 2‐ pyridyl phosphates into the corresponding 3‐hydroxy‐4‐pyridyl‐and 2‐hydroxy‐3‐pyridylphosphonates has been observed and investigated. The rearrangement is proposed as a useful method for a directed introduction of a phosphoryl group into a hydroxypyridine nucleus.

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