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1,3-Dipolar cycloaddition reaction: Synthesis of novel 5,6-dehydronorcantharidin derivatives of substituted aromatic amines with potential antitumor activities

✍ Scribed by Li-Ping Deng; Fang-Ming Liu; Hou-Yong Wang


Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
92 KB
Volume
42
Category
Article
ISSN
0022-152X

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✦ Synopsis


Twelve novel compounds were synthesized by the [3+2] 1,3-dipolar cycloaddition reaction of 5,6-dehydronorcantharidin derivatives of substituted aromatic amines with nitrile oxides. The structure and the configuration of all compounds were confirmed by 1 H NMR, IR, MS, 1 H-1 HCOSY, and NOESY spectral data. Their anti-tumor activities are under way.


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