1,3-Dipolar cycloaddition reaction: Synthesis of novel 5,6-dehydronorcantharidin derivatives of substituted aromatic amines with potential antitumor activities
β Scribed by Li-Ping Deng; Fang-Ming Liu; Hou-Yong Wang
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2005
- Tongue
- English
- Weight
- 92 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-152X
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β¦ Synopsis
Twelve novel compounds were synthesized by the [3+2] 1,3-dipolar cycloaddition reaction of 5,6-dehydronorcantharidin derivatives of substituted aromatic amines with nitrile oxides. The structure and the configuration of all compounds were confirmed by 1 H NMR, IR, MS, 1 H-1 HCOSY, and NOESY spectral data. Their anti-tumor activities are under way.
π SIMILAR VOLUMES
## Abstract magnified image Highly efficient, practical and convenient synthesis of twelve compounds by the [3+2] 1, 3βdipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with two hydrazines in the presence of chloramineβT. J. Heterocyclic Chem., (2009).
## Abstract magnified image Highly efficient, practical and convient synthesis of fifteen compounds by the [3+2] 1,3βdipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with three hydrazines in the presence of ChloramineβT.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
## Abstract magnified image A series of eighteen novel compounds that have potential pharmacological properties has been synthesized by 1,3βdipolar cycloaddition reactions of 5,6βdehydronorcantharidin derivatives of substituted aromatic amine with nitrile oxide. The synthesis was carried out follo