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1,3-Dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes

โœ Scribed by Kim, Hea O.; Schinazi, Raymond F.; Nampalli, Satyanarayana; Shanmuganathan, Kirupathevy; Cannon, Deborah L.; Alves, Antonio J.; Jeong, Lak S.; Beach, J. Warren; Chu, Chung K.


Book ID
111869153
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
1020 KB
Volume
36
Category
Article
ISSN
0022-2623

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In view of biological activities of both 1,3-dioxolanyl nucleosides and C-nucleosides, D-and L-I ,3dioxolanyl C-nucleosides have been synthesized as potential antiviral and/or anticancer agents. Asymmetrie Synthesis of four new optically pure D-and L-1,3-dioxolanyl triazole C-nucleosides has been ac