1,3-Diaza-1,3-butadienes. Synthesis and Conversion into Pyrimidines by [4π + 2π] Cycloaddition with Electron Deficient Acetylenes. Synthetic Utility of 2-(Trichloromethyl)pyrimidines 1
✍ Scribed by Guzmán, Angel; Romero, Moisés; Talamás, Francisco X.; Villena, Rene; Greenhouse, Robert; Muchowski, Joseph M.
- Book ID
- 125502677
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 582 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
2-Trichloromethyl-4-dimethylamino-1,3-diaza-l,3-butadienes(3),prepared from trichlomacetamidme(1) and amide acetals 2, readily react with electron d&ie.nt acetylenes 4 to give 2-trichloromethylpyrimidines 5.
A facile oxime-nitrone isomerization through the 1,2-hydrogen shift in 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde oximes is discussed. The resultant NH-nitrones are trapped by maleimides to afford intermolecular cycloadducts. The reaction of the oximes with electron-deficient acetylenes undergo