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1,3-cycloaddition reactions of 2-oxo-2H-[1]benzopyran-4-carbonitrile N-oxide. Synthesis of several new 4-substituted coumarins

✍ Scribed by Demetrios N. Nicolaides; Konstantina C. Fylaktakidou; Konstantinos E. Litinas; George K. Papageorgiou; Dimitra J. Hadjipavlou-Litina

Book ID
102892854
Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
527 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

1,3‐Cycloaddition reactions of new 2‐oxo‐2__H__‐[1]benzopyran‐4‐carbonitrile N‐oxide 2 with dipolarophiles, o‐aminophenols and o‐phenylenediamine resulted in 4‐heterocyclic substituted coumarin derivatives. These derivatives are screened for antiinflammatory activity in vitro through their antiproteolytic activity, the interaction with 1,1‐diphenyl‐2‐picrylhydrazyl and the ability to affect superoxide anion and to inhibit β‐glucuronidase and soybean lipoxygenase.

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✍ Tarun Ghosh; Chandrakanta Bandyopadhyay 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Reactions of 2-amino-4h-1-benzopyran-4-o
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✍ Tarun Ghosh; Chandrakanta Bandyopadhyay 📂 Article 📅 2006 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 267 KB 👁 1 views

## Abstract magnified image The title aldehyde **1** reacts smoothly with the enamine moiety of **2**‐aminochromone **2** to produce hitherto unreported 3‐(2‐hydroxybenzoyl)‐5__H__‐1‐benzopyrano[2,3‐__b__]pyridin‐5‐one (azaxanthone) **5**. This reaction has been extended for the synthesis of bisaz