1,3-Cycloaddition of Benzonitrile oxides to diazepines.II. 1-ethoxycarbonyl-4-methyl- and 6-methyl-1,2-diazepine
✍ Scribed by Paolo Beltrame; Enzo Cadoni; Costantino Floris; Gioanna Gelli
- Book ID
- 108371888
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 908 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract An efficient asymmetric synthesis of (__R__)‐6‐amino‐1‐methyl‐4‐(3‐rnethylbenzyl)hexahydro‐1__H__‐1,4‐diazepine [(__R__)‐2] which serves as the amine part of (__R__)‐1, a potent and selective 5‐HT~3~ receptor antagonist, is described. Formation of the hexahydro‐1__H__‐1,4‐diazepine ring
In the title compound, C 11 H 12 N 4 , the diazepine ring exhibits a boat conformation, where the displacements of the C atoms attached to the nitrile groups and the C atom attached to the ethyl group are 0.591 (1), 0.585 (1) and 0.845 (1) A Ê from the base of the boat.