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Efficient synthesis of (R)-6-benzyloxycarbonylamino-1-methyl-4-(3-methyl-benzyl)hexahydro-1,4-diazepine. 2. Novel formation of hexahydro-1,4-diazepine ring using 1,2,3-trisubstituted aminopropane derivative and glyoxal

โœ Scribed by Hiroshi Harada; Toshiya Morie; Toshifumi Suzuki; Toyokichi Yoshida; Shiro Kato


Book ID
108379066
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
306 KB
Volume
54
Category
Article
ISSN
0040-4020

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๐Ÿ“œ SIMILAR VOLUMES


Asymmetric synthesis of (R)-6-amino-1-me
โœ Shiro Kato; Hiroshi Harada; Toshiya Mode ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 772 KB

## Abstract An efficient asymmetric synthesis of (__R__)โ€6โ€aminoโ€1โ€methylโ€4โ€(3โ€rnethylbenzyl)hexahydroโ€1__H__โ€1,4โ€diazepine [(__R__)โ€2] which serves as the amine part of (__R__)โ€1, a potent and selective 5โ€HT~3~ receptor antagonist, is described. Formation of the hexahydroโ€1__H__โ€1,4โ€diazepine ring