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1,3-Butadiene metabolism by lung airways isolated from mice and rats

✍ Scribed by M.J. Seaton; C.G. Plopper; J.A. Bond

Book ID: 107939075
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 296 KB
Volume: 113
Category: Article
ISSN: 0300-483X
DOI: 10.1016/0300-483x(96)03464-6

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Metabolism of 1,3-butadiene to 1,2-epoxybutene-3 in rats follows saturation kinetics. Comparative investigation of inhalation pharmacokinetics in mice also revealed a saturation pattern. For both species "linear" pharmacokinetics apply at exposure concentrations below 1000 ppm 1,3-butadiene; saturat