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1,3-Bis(3,4,5-trimethoxy­phen­yl)-2,3-epoxy­propanone: an anti­cancer chalcone epoxide

✍ Scribed by Cuthbertson, Timothy ;Groy, Thomas L. ;Rose, Seth D.

Publisher
International Union of Crystallography
Year
2005
Tongue
English
Weight
274 KB
Volume
61
Category
Article
ISSN
1600-5368

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✦ Synopsis

The title compound, C 21 H 24 O 8 , crystallizes as colorless needles composed of a racemic mixture that adopts the packing order of columns of alternating enantiomers, all of whose oxirane rings are essentially aligned. Within each column, the carbonyl groups of adjacent enantiomers are oriented in nearly opposite directions. The structure is stabilized by several C-HÁ Á ÁO associations.

📜 SIMILAR VOLUMES

(E)-1-(2-Hydroxy­phen­yl)-3-(3,4,5-trime
(E)-1-(2-Hydroxy­phen­yl)-3-(3,4,5-trimethoxy­phen­yl)prop-2-en-1-one
✍ Wu, Hui ;Xu, Zhou ;Liang, Yong-Min 📂 Article 📅 2005 🏛 International Union of Crystallography 🌐 English ⚖ 294 KB

The title compound, C 18 H 18 O 5 , was prepared by the condensation of 2-hydroxyacetophenone with 3,4,5-trimethoxybenzaldehyde. The trimethoxyphenyl and hydroxyphenyl rings of the chalcone system are approximately coplanar.

1-(4-Chloro­phen­yl)-3-(2,4,5-trimethoxy
1-(4-Chloro­phen­yl)-3-(2,4,5-trimethoxy­phen­yl)prop-2-en-1-one
✍ Patil, P. S. ;Ng, Shea-Lin ;Razak, Ibrahim Abdul ;Fun, Hoong-Kun ;Dharmaprakash, 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 130 KB

The title molecule, C 18 H 17 ClO 4 , is slightly distorted from planarity. The dihedral angle between the two benzene rings is 11.6 (2) . The crystal packing is stabilized by C-HÁ Á Á interactions and van der Waals forces.

1-(4-Bromo­phen­yl)-3-(2,4,5-trimethoxy­
1-(4-Bromo­phen­yl)-3-(2,4,5-trimethoxy­phen­yl)prop-2-en-1-one
✍ Patil, P. S. ;Rosli, Mohd Mustaqim ;Fun, Hoong-Kun ;Razak, Ibrahim Abdul ;Dharma 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 394 KB

In the title compound, C 18 H 17 BrO 4 , the dihedral angle between the benzene rings is 9.60 (16) . The crystal structure is stabilized by intermolecular C-HÁ Á ÁO interactions and BrÁ Á ÁO short contacts.

1-(4-Fluoro­phen­yl)-3-(2,4,5-trimethoxy
1-(4-Fluoro­phen­yl)-3-(2,4,5-trimethoxy­phen­yl)prop-2-en-1-one
✍ Teh, Jeannie Bee-Jan ;Patil, P. S. ;Fun, Hoong-Kun ;Razak, Ibrahim Abdul ;Dharma 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 238 KB

In the title compound, C 18 H 17 FO 4 , the dihedral angle between the benzene rings is 12.42 (2) . The crystal structure is stabilized by C-HÁ Á ÁO, C-HÁ Á Á andinteractions.

1-(4-Chloro­phen­yl)-3-(2,4,5-trimethoxy
1-(4-Chloro­phen­yl)-3-(2,4,5-trimethoxy­phen­yl)prop-2-en-1-one
✍ Teh, Jeannie Bee-Jan ;Patil, P. S. ;Fun, Hoong-Kun ;Razak, Ibrahim Abdul ;Dharma 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 291 KB

In the title compound, C~18~H~16~Cl~2~O~4~, the dihedral angle between the benzene rings is 65.9 (1)°. The crystal packing is stabilized by intermolecular C—H...O interactions.