1,3-Asymmetric induction in enolate alkylation reactions of N-protected γ-amino acid derivatives
✍ Scribed by Stephen Hanessian; Robert Schaum
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 239 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Dianions derived from N-Cbz and N-Boc glutamic acid esters undergo highly stereoselective anti allylation reactions at C-4. The roles of protecting groups and of the electrophile were studied. Synthetic applications and potential utility in peptidomimetic design are also described.
Dianions derived from N-Cbz aspartic acid esters undergo highly stereoselective ant/ allylation reactions at the unsubstituted carbon. The roles of additives, of the cation and of the electrophile were studied Synthetic applications and potential utility in peptidomimetic design are also described.