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13 Acetylcholine activates phosphatidylinositol 3-kinase via transactivation of the EGF receptor

✍ Scribed by Thomas Krieg; Qining Qin; Michael V. Cohen; James M. Downey


Book ID
117141830
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
140 KB
Volume
34
Category
Article
ISSN
0022-2828

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## Abstract Many G protein coupled receptors (GPCRs) cause phosphorylation of MAP kinases through transactivation of the epidermal growth factor receptor (EGF‐R), leading to increased cell survival and growth, motility, and migration. Phosphoinositide 3‐kinase (PI3K) is one of the important cell su