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12S,19- and 12S,20-dihydroxyeicosanoids: Novel 12S-hydroxy-5,8-cis-10-trans-14-cis-eicosatetraenoic acid metabolites formed by hydroxylation and reduction in murine lymphocytes

โœ Scribed by Roberta M. Danilowicz; Gregory Reed; Dori R. Germolec; Michael I. Luster; Kenneth B. Tomer; John F. Curtis; Tetsuo Higuchi; Thomas E. Eling


Book ID
115708124
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
1002 KB
Volume
271
Category
Article
ISSN
0003-9861

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Synthesis of 12(S),20-, 12(S),19(R)-, an
โœ Sukumar Manna; Jacques Viala; Pendri Yadagiri; J.R Falck ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 231 KB

Enantiospecific syntheses of the ZO-and both 19-hydroxy metabolites of 12(S)-HETE were accomplished using readily available, chiral precursors. Recently, a new metabolite of 12(S)-hydroxyeicosatetraenoic (12-HETE) acid (1) was isolated from the coincubation of human platelets and neutrophils with ar